SML0440

Spautin-1

≥98% (HPLC)

• Synonyme(s) : 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43
• Formule empirique (notation de Hill) : C₁₅H₁₁F₂N₃
• CAS Number: 1262888-28-7
• Poids moléculaire : 271.26
• Numéro MDL: MFCD16962292
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824722
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 15 mg/mL (clear solution)
• Température de stockage: 2-8°C
• Chaîne SMILES: FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
• InChI: 1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
• Clé InChI: AWIVHRPYFSSVOG-UHFFFAOYSA-N

Description

Application

Spautin-1 has been used as an autophagy inhibitor:

• to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
• to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
• to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Actions biochimiques/physiologiques

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.

Spautin-1 is an inhibitor of autophagy.

Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H318
• Conseils de prudence: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Classification des risques: Acute Tox. 4 Oral - Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable