SML0527

Epalrestat

≥98% (HPLC)

• Synonyme(s) : (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
• Formule empirique (notation de Hill) : C₁₅H₁₃NO₃S₂
• CAS Number: 82159-09-9
• Poids moléculaire : 319.40
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: yellow to orange
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: −20°C
• Chaîne SMILES: S1\C(=C/C(=C/c2ccccc2)/C)\C(=O)N(C1=S)CC(=O)O
• InChI: 1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
• Clé InChI: CHNUOJQWGUIOLD-NFZZJPOKSA-N

Description

Application

Epalrestat has been used as an aldose reductase inhibitor:

• in the dahomey larvae diet fed forDrosophila
• for non-irradiated and X-ray irradiated human aldose reductase
• to test its protective effect in mice with bleomycin-induced pulmonary fibrosis

Actions biochimiques/physiologiques

Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.

Epalrestat is an Aldose Reductase inhibitor.

Caractéristiques et avantages

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Autres remarques

Light sensitve

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable