SML0627

ML-SA1

≥95% (HPLC), powder, TRPML channel agonist

• Synonyme(s) : 1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1
• Formule empirique (notation de Hill) : C₂₂H₂₂N₂O₃
• CAS Number: 332382-54-4
• Poids moléculaire : 362.42
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: ML-SA1, ≥95% (HPLC)
• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: N3(C(=O)c4c(cccc4)C3=O)CC(=O)N1C(CC(c2c1cccc2)C)(C)C
• InChI: 1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
• Clé InChI: KDDHBJICVBONAX-UHFFFAOYSA-N

Description

Application

ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.

Actions biochimiques/physiologiques

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca²⁺]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable