SML0814

ESI-09

≥98% (HPLC)

• Synonyme(s) : α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
• Formule empirique (notation de Hill) : C₁₆H₁₅ClN₄O₂
• CAS Number: 263707-16-0
• Poids moléculaire : 330.77
• Code UNSPSC : 41106305
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: , faint yellow to dark orange
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: Clc1cc(ccc1)N\N=C(\C(=O)c2n[o]c(c2)C(C)(C)C)/C#N
• InChI: 1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
• Clé InChI: DXEATJQGQHDURZ-DEDYPNTBSA-N

Description

Application

ESI-09 has been used as an antagonist for exchange factor directly activated by cAMP (EPAC).

Actions biochimiques/physiologiques

ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP).

ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC₅₀ values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable