SML0837

FAK Inhibitor 14

≥95% (HPLC)

• Synonyme(s) : 1,2,4,5-Benzene tetraamine tetrahydrochloride, 1,2,4,5-Benzenetetraamine 4HCl, 1,2,4,5-Benzenetetraamine tetrahydrochloride, Benzene-1,2,4,5-tetramine tetrahydrochloride, NSC 667249, Y15
• Formule empirique (notation de Hill) : C₆H₁₀N₄ · 4HCl
• CAS Number: 4506-66-5
• Poids moléculaire : 284.01
• Numéro CE : 224-822-6
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: , faint purple to dark brown
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: [Cl-].[Cl-].[Cl-].[Cl-].Nc1c(cc(c(c1)N)N)N.[H+].[H+].[H+].[H+]
• InChI: 1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H
• Clé InChI: BZDGCIJWPWHAOF-UHFFFAOYSA-N

Description

Application

FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion.

Actions biochimiques/physiologiques

1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor.

1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable