SML1232

cGAMP sodium salt

≥98% (HPLC)

• Synonyme(s) : 3′3′-cGAMP sodium salt, Cyclic AMP-GMP sodium salt, c-GMP-AMP sodium salt, cyclic GMP-AMP sodium salt
• Formule empirique (notation de Hill) : C₂₀H₂₄N₁₀O₁₃P₂ · xNa⁺
• CAS Number: 849214-04-6
• Poids moléculaire : 674.41 (free acid basis)
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825735
• Nomenclature NACRES : NA.77

Propriétés

• Description: contains 0.5μmol of powder (approx. 0.335mg)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Température de stockage: −20°C
• Chaîne SMILES: O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP4(O)=O)[C@H]3COP(O)(O[C@H]5[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O[C@@H]5CO4)=O.C

Description

Application

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

Actions biochimiques/physiologiques

Cyclic AMP-GMP (cGAMP) is a bacterial second messenger.

Cyclic AMP-GMP (cGAMP) is one of several naturally occurring cyclic dinucleotides that act as a bacterial second messengers to regulate important signaling mechanisms in prokaryotes that control bacterial survival, adhesion, colonization, biofilm formation, and virulence factors production. In cholera c-AMP-GMP promotes intestinal colonization by down-regulating chemotaxis. During infections bacterial cGAMP is bound by host STING (stimulator of interferon genes) activating innate immune responses leading to expression of interferon genes.

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8⁺ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

Notes préparatoires

Cyclic AMP-GMP is soluble in water and aqueous buffers (> 10 mM, limits have not been determined).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable