SML1314

SAG dihydrochloride

≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist

• Synonyme(s) : 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide dihydrochloride, Smoothened Agonist
• Formule empirique (notation de Hill) : C₂₈H₂₈ClN₃OS · 2HCl
• CAS Number: 912545-86-9
• Poids moléculaire : 562.98
• Code UNSPSC : 51111800
• ID de substance PubChem : 329825779
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: SAG dihydrochloride, ≥98% (HPLC)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: lyophilized solid
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
• InChI: 1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
• Clé InChI: VFSUUTYAEQOIMW-YHBQERECSA-N

Description

Application

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:

• to study its effects on mouse hippocampal cells
• to determine its effects on the mitochondrial network in zebrafish embryo
• to study its effects on murine embryonic fibroblasts

Actions biochimiques/physiologiques

SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.

SAG is a potent and cell-permeable smoothened (Smo) agonist.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301,H413
• Conseils de prudence: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral - Aquatic Chronic 4
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable