SML1396

Heclin

≥98% (HPLC)

• Synonyme(s) : N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
• Formule empirique (notation de Hill) : C₁₇H₁₇NO₃
• CAS Number: 890605-54-6
• Poids moléculaire : 283.32
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825844
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O
• InChI: 1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+
• Clé InChI: SPTWXRJNCFIDRQ-ZHACJKMWSA-N

Description

Application

Heclin has been used as a HECT-type ubiquitin E3 ligase inhibitor in human embryonic kidney (HEK293) cells. It has also been used to test its effect on dandelion-induced chloride channel protein (ClC-Ka) inhibition in HEK293 cells and fibroblast-like COS-7 cell line.

Actions biochimiques/physiologiques

HECT E3 ubiquitin ligase inhibitor

Heclin is a selective reversible inihbitor of HECT E3 ubiquitin ligases. Heclin inhibited Nedd4, Smurf2 and WWP1 with IC₅₀ values of 6.3 μM, 6.8 μM and 6.9 μM, respectively, and inhibited autoubiquitination of the Smurf2 HECT domain in vivo with an IC₅₀ value of 9 μM. Heclin had no effect on the auto-ubiquitination of the RING domain ligase Mdm2.

Heclin is not effective in inhibiting E1 or E2 proteins.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable