SML1466

ABH hydrochloride

≥98% (HPLC)

• Synonyme(s) : 2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride
• Formule empirique (notation de Hill) : C₆H₁₄BNO₄ · HCl
• CAS Number: 194656-75-2
• Poids moléculaire : 211.45
• Numéro MDL: MFCD22887376
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825900
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D +8 to +13°, c = 0.7 in H₂O
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
• InChI: 1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
• Clé InChI: XCUVEZUCSHVMRK-JEDNCBNOSA-N

Description

Actions biochimiques/physiologiques

ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.

ABH is a highly potent and specific arginase inhibitor

Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable