SML1594

Cilengitide trifluoroacetic acid salt

≥95% (HPLC)

• Synonyme(s) : 2,2,2-trifluoroacetate, Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl), 2,2,2-trifluoroacetate, EMD 121974, NSC 707544, c(RGDF(NMe)V)
• Formule empirique (notation de Hill) : C₂₇H₄₀N₈O₇ · xC₂HF₃O₂
• CAS Number: 188968-51-6
• Poids moléculaire : 588.66 (free base basis)
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: N1([C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C1=O)Cc2ccccc2)CC(=O)O)CCCN\C(=N\[H])\N)C(C)C)C
• InChI: 1S/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1
• Clé InChI: AMLYAMJWYAIXIA-VWNVYAMZSA-N

Description

Application

Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin αvβ5.

Actions biochimiques/physiologiques

Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist.

Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist. Cilengitide is a cyclized Arg-Gly-Glu(RGD)-containing pentapeptide that selectively blocks activation of the αvβ3 and αvβ5 integrins.

It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3