SML1657

Gefitinib

≥98% (HPLC), powder, EGFR TK inhibitor

• Synonyme(s) : N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine, ZD1839
• Formule empirique (notation de Hill) : C₂₂H₂₄ClFN₄O₃
• CAS Number: 184475-35-2
• Poids moléculaire : 446.90
• Numéro MDL: MFCD04307832
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825996
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Gefitinib, ≥98% (HPLC)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: COC(C=C(N=CN=C1NC2=CC(Cl)=C(F)C=C2)C1=C3)=C3OCCCN4CCOCC4
• InChI: 1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
• Clé InChI: XGALLCVXEZPNRQ-UHFFFAOYSA-N
• Informations sur le gène: human ... EGFR(1956)

Description

Application

Gefitinib has been used :

• To study its effective use in endometrial cancer therapy
• Cell proliferation, cell cycle and apoptosis assays
• Cell viability assay and colony formation assay

Actions biochimiques/physiologiques

Gefitinib is a selective epidermal growth factor receptor tyrosine kinase (EGFR TK) inhibitor. Gefitinib has antineoplastic activity, and has been approved for the treatment on non-small cell lung cancer (NSCLC).
Gefitinib has a higher affinity for ATP (adenosine triphosphate) binding site in the EGFR tyrosine kinase domain than ATP. Hence, gefitinib is known to inhibit the progression of endometrial cancer.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H318,H351,H360Fd,H373,H410
• Conseils de prudence: P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable