SML1909

RS 23597-190

≥98% (HPLC)

• Synonyme(s) : 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride, RS 23597, RS-23,597-190, RS-23597, RS-23597-190, RS23597, RS23597-190
• Formule empirique (notation de Hill) : C₁₆H₂₃ClN₂O₃ · HCl
• CAS Number: 149719-06-2
• Poids moléculaire : 363.28
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 5 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: [Cl-].Clc1c(cc(c(c1)C(=O)OCCCN2CCCCC2)OC)N.[H+]
• InChI: 1S/C16H23ClN2O3.ClH/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-5-8-19-6-3-2-4-7-19;/h10-11H,2-9,18H2,1H3;1H
• Clé InChI: QLZLBYYNMGQIAR-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy.

RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable