Accéder au contenu
MilliporeSigma

Principaux documents

Voir toute la documentation

Passer à

SML1922

Sigma-Aldrich

K67

≥98% (HPLC)

Synonyme(s) :

2-Acetonyl-1,4-bis[(4-ethoxybenzensulfonyl)amino]naphthalene, N,N′-(2-(2-Oxopropyl)naphthalene-1,4-diyl)bis(4-ethoxybenzenesulfonamide), N-[2-Acetonyl-4-(4-ethoxybenzenesulfonylamino)naphthalene-1-yl]-4-ethoxybenzenesulfonamide

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

About This Item

Formule empirique (notation de Hill) :
C29H30N2O7S2
CAS Number:
2046250-48-8
Poids moléculaire :
582.69
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: 10 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

CC(CC1=C(NS(C2=CC=C(OCC)C=C2)(=O)=O)C3=C(C=CC=C3)C(NS(C4=CC=C(OCC)C=C4)(=O)=O)=C1)=O

Clé InChI

VUIVGOOWLHGDPZ-UHFFFAOYSA-N

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 4

Cet article
220915141422095
Tryptic Soy Agar - Dehydrated Culture Media NutriSelect® Plus, (Vegitone), powder, suitable for microbiology

14432

Tryptic Soy Agar - Dehydrated Culture Media

Tryptic Soy Agar - Dehydrated Culture Media NutriSelect® Plus, powder, suitable for microbiology

22091

Tryptic Soy Agar - Dehydrated Culture Media

modified Tryptic Soy Agar- Dehydrated Culture Media NutriSelect® Plus, lecithin, polysorbate 80 (Tween® 80), powder, suitable for microbiology

51414

modified Tryptic Soy Agar- Dehydrated Culture Media

CASO Agar NutriSelect® Plus, powder, suitable for microbiology

22095

CASO Agar

application(s)

agriculture
bioburden testing
cleaning products
clinical testing
cosmetics
environmental
food and beverages
industrial hygiene
personal care
pharmaceutical
surface monitoring
veterinary, microbiology

application(s)

agriculture
bioburden testing
cleaning products
clinical testing
cosmetics
environmental
food and beverages
personal care
surface monitoring
veterinary, microbiology

application(s)

cleaning products
clinical testing
cosmetics
environmental
food and beverages
personal care
pharmaceutical
sterility testing
surface monitoring, microbiology

application(s)

bioburden testing
cleaning products
clinical testing
cosmetics
environmental
food and beverages
personal care
pharmaceutical
surface monitoring
veterinary
water monitoring, microbiology

suitability

Haemophilus spp., nonselective for Bacillus spp., nonselective for Campylobacter spp., nonselective for Escherichia coli, nonselective for Staphylococcus spp., nonselective for bacteria (General Media), Enterococcus spp., nonselective for Bacteroides spp., nonselective for Neisseria spp., nonselective for coliforms, Pneumococcus spp., nonselective for Streptococcus spp., nonselective for Candida spp.

suitability

Enterococcus spp., Haemophilus spp., Pneumococcus spp., nonselective for Bacillus spp., nonselective for Bacteroides spp., nonselective for Campylobacter spp., nonselective for Candida spp., nonselective for Cronobacter spp., nonselective for Escherichia coli, nonselective for Neisseria spp., nonselective for Staphylococcus spp., nonselective for Streptococcus spp., nonselective for bacteria (General Media), nonselective for coliforms

suitability

Micrococcus spp., nonselective for Aspergillus spp., nonselective for Bacillus spp., nonselective for Candida spp., nonselective for Enterococcus spp., nonselective for Escherichia coli, nonselective for Pseudomonas spp., nonselective for Salmonella spp., nonselective for Serratia spp., nonselective for Staphylococcus spp., nonselective for Streptococcus spp., nonselective for bacteria (General Media), nonselective for coliforms

suitability

Enterococcus spp., Haemophilus spp., Pneumococcus spp., nonselective for Bacillus spp., nonselective for Bacteroides spp., nonselective for Campylobacter spp., nonselective for Candida spp., nonselective for Escherichia coli, nonselective for Neisseria spp., nonselective for Staphylococcus spp., nonselective for Streptococcus spp., nonselective for bacteria (General Media), nonselective for coliforms

biological source

(Vegitone)

biological source

-

biological source

-

biological source

-

technique(s)

microbe id | specific enzyme detection: suitable, microbiological culture: suitable

technique(s)

microbe id | specific enzyme detection: suitable, microbiological culture: suitable

technique(s)

-

technique(s)

microbe id | specific enzyme detection: suitable, microbiological culture: suitable

form

powder

form

powder

form

powder

form

powder

manufacturer/tradename

NutriSelect® Plus

manufacturer/tradename

NutriSelect® Plus

manufacturer/tradename

NutriSelect® Plus

manufacturer/tradename

NutriSelect® Plus

Actions biochimiques/physiologiques

K67 is a specific inhibitor against the interaction between KEAP1 (Kelch-like ECH-associated protein 1) DC (double glycine repeat and C-terminal region) domain and S349-phosphorylated (human Ser349, mouse Ser351) KIR (Keap1-interacting region) of p62/SQSTM1, thereby preventing phospho-p62 from blocking KEAP1-DC and NRF2 (nuclear factor erythroid 2-related factor 2) DLGex motif association. K67 effectively inhibits the proliferation of HCC (hepatocellular carcinoma) cultures (by 59% of Huh7 cells post 72 h 50 μM K67 treatment) with high cellular p62 S351-phosphorylation by restoring KEAP1-driven NRF2 ubiquitination and degradation.
K67 is a specific inhibitor against the interaction between KEAP1 (Kelch-like ECH-associated protein 1) DC (double glycine repeat and C-terminal region) domain and S349-phosphorylated (human Ser349, mouse Ser351) KIR (Keap1-interacting region) of p62/SQSTM1.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

  • Fiche des caractéristiques

    • Faites votre choix parmi les versions les plus récentes :

    Certificats d'analyse (COA)

    Lot/Batch Number
    047M4602V

    Vous ne trouvez pas la bonne version ?

    Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

    Rechercher un(e) COA

    Déjà en possession de ce produit ?

    Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

    Consulter la Bibliothèque de documents

    Deniz Bagdas et al.
    Behavioural pharmacology, 22(5-6), 589-598 (2011-08-13)
    This study was designed to test the effects of intracerebroventricularly (i.c.v.) administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain. The i.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 µmol) produced a dose and
    Tomás Sobrino et al.
    Neurological research, 33(6), 572-577 (2011-06-29)
    The increase in circulating endothelial progenitor cells (EPCs) is associated with a better outcome in patients with acute ischemic stroke. CDP-choline (citicoline) increases brain plasticity after experimental stroke. Therefore, we study if citicoline treatment could increase the EPC concentration after
    Erhan Aslan et al.
    Neurological research, 33(7), 766-773 (2011-07-16)
    Topical cytidine-5'-diphosphocholine (CDP-choline) has been shown to improve the functional recovery and promote the nerve regeneration of injured sciatic nerves in rats. The aims of this study were to test whether CDP-choline was effective at promoting nerve healing when the
    Lorissa J Niebergall et al.
    Biochimica et biophysica acta, 1811(12), 1177-1185 (2011-07-13)
    Several studies suggest that low levels of hepatic phosphatidylcholine (PC) play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Liver-specific elimination of CTα
    Patricia M Arenth et al.
    PM & R : the journal of injury, function, and rehabilitation, 3(6 Suppl 1), S123-S131 (2011-07-08)
    Cytidine 5'-diphosphocholine (CDP-choline or citicoline) is a highly bioavailable compound with potential benefits for aiding neural repair and increasing acetylcholine levels in the central and peripheral nervous system. As a result, many researchers have investigated the use of CDP-choline for

    Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

    Contacter notre Service technique