SML2064

LBQ657

≥97% (HPLC)

• Synonyme(s) : (2R,4S)-5-(Biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid, Desethyl sacubitril, Sacubitrilat
• Formule empirique (notation de Hill) : C₂₂H₂₅NO₅
• CAS Number: 149709-44-4
• Poids moléculaire : 383.44
• Numéro MDL: MFCD00921225
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥97% (HPLC)
• Forme: powder
• Activité optique: [α]/D -35 to -27°, c = 1 in methanol
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: OC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O
• InChI: 1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
• Clé InChI: DOBNVUFHFMVMDB-BEFAXECRSA-N

Description

Actions biochimiques/physiologiques

Inhibitor of neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377)

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H336,H372
• Conseils de prudence: P260 - P264 - P271 - P304 + P340 + P312 - P314 - P403 + P233
• Classification des risques: STOT RE 1 - STOT SE 3
• Organes cibles: Bone,Kidney, Central nervous system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable