SML2140

TCS 401

≥98% (HPLC)

• Synonyme(s) : 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride, TCS-401, TCS401
• Formule empirique (notation de Hill) : C₁₀H₁₀N₂O₅S · xHCl
• CAS Number: 243966-09-8
• Poids moléculaire : 270.26 (free base basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: 0.1 M NaOH: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: [s]1c2c(c(c1NC(=O)C(=O)O)C(=O)O)CC[N+H2]C2.[Cl-]
• Clé InChI: LQGCAMWQDSYOAY-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B); insulin receptor sensitizing agent.

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B), which plays a key role in the negative regulation of the insulin signaling pathway, contributing to insulin resistance. It exhibited Ki values of 290 nM for PTP1B, with greater than 100-fold or more selectivity compared to other phosphatases. Inhibition of PTP1B by TCS 401 has been shown to sensitize the insulin signaling pathway and increase dopamine release in response to insulin. TCS-401 has also been shown to promote endothelial cell motility and to induce differentiation of retinal pigment epithelial cells toward improved contractility and motility.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable