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SML2731

Sigma-Aldrich

alpha-NETA

≥98% (HPLC)

Synonyme(s) :

α-NETA, 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide, N,N,N-Trimethyl-γ-oxo-1-naphthalenepropanaminium iodide, N,N,N-Trimethyl-3-(naphthalen-1-yl)-3-oxopropan-1-aminium iodide, a-NETA

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About This Item

Formule empirique (notation de Hill) :
C16H20INO
CAS Number:
Poids moléculaire :
369.24
Numéro MDL:
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
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Niveau de qualité

Essai

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

DMSO: 2 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

O=C(C1=CC=CC2=C1C=CC=C2)CC[N+](C)(C)C.[I-]

InChI

1S/C16H20NO.HI/c1-17(2,3)12-11-16(18)15-10-6-8-13-7-4-5-9-14(13)15;/h4-10H,11-12H2,1-3H3;1H/q+1;/p-1

Clé InChI

QZXMJYVXMZJOAO-UHFFFAOYSA-M

Catégories apparentées

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1 of 4

Cet article
589373486973486965
assay

99% (CP)

assay

-

assay

99% (CP)

assay

99% (CP)

mass shift

M+2

mass shift

M+2

mass shift

M+1

mass shift

M+1

isotopic purity

98 atom % D

isotopic purity

99 atom % 13C

isotopic purity

99 atom % 13C

isotopic purity

99 atom % 13C

density

1.032 g/mL at 25 °C

density

1.032 g/mL at 25 °C

density

1.024 g/mL at 25 °C

density

1.024 g/mL at 25 °C

bp

233-234 °C (lit.)

bp

233-234 °C (lit.)

bp

233-234 °C (lit.)

bp

233-234 °C (lit.)

mp

-24 °C (lit.)

mp

-24 °C (lit.)

mp

−24 °C (lit.)

mp

−24 °C (lit.)

Actions biochimiques/physiologiques

Originally identified as a substrate (ChA or choline)-noncompetitive, slowly reversible choline acetyltransferase inhibitor (human ChAT/BuChE/AChE IC50 = 88 nM/33.3 μM/48.6 μM; does not affect mAChRs, AChE, ChE, CrAT, ganglionic or skeletal muscular nAChRs), α-NETA is a fluorescent molecule (Ex 255 & 297 nm; Em 427 nm) also known for its trace amine-associated receptor 5 (TAAR5 EC50 = 150 nM) agonist and chemokine-like receptor-1 antagonist (IC50 = 375 nM; 7 nM chemerin-induced CMKLR1 β-ARR2 recruitment) potencies both in cultures and in animal disease models in vivo (3-20 mg/kg via ip. or sc. in rats & mice).
Potent ChAT inhibitor, TAAR5 agonist, CMKLR1 (ChemR23) antagonist with in vivo efficacies in animal disease models.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Wouter Huvenne et al.
Respiratory research, 11, 100-100 (2010-07-24)
Cigarette smoke (CS) is known to initiate a cascade of mediator release and accumulation of immune and inflammatory cells in the lower airways. We investigated and compared the effects of CS on upper and lower airways, in a mouse model
N F Li et al.
Cell proliferation, 40(5), 780-794 (2007-09-20)
Cell immortalization is considered to be a prerequisite status for carcinogenesis. Normal human ovarian surface epithelial (OSE) cells, which are thought to be the origin of most of human ovarian carcinomas, have a very limited lifespan in culture. Establishment of
Vijay G Ramakrishnan et al.
Journal of biomolecular techniques : JBT, 16(4), 297-305 (2006-03-09)
Ticks are obligate ectoparasites that feed on a variety of hosts including mammals, birds and reptiles. Prolonged attachment on the host and an ability to transmit a wide variety of pathogens are the special features of tick feeding. Salivary glands
M Otsuka et al.
The Journal of biological chemistry, 275(44), 34122-34130 (2000-08-05)
Hepatitis C virus (HCV) causes a persistent infection, chronic hepatitis, and hepatocellular carcinoma. Since there are several reports indicating that some viruses influence the tumor suppressor p53 function, we determined the effects of HCV proteins on p53 function and its
Axel Hoos et al.
The American journal of pathology, 160(1), 175-183 (2002-01-12)
Hürthle cell tumors are rare thyroid neoplasms for which disease biology is poorly understood and diagnosis of carcinoma can be challenging. The aim of the study was to characterize molecular expression profiles of Hürthle cell tumors and to determine the

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