SRP2102

TNFα, low endotoxin, His tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonyme(s) : DIF, TNF-alpha, TNFA, TNFSF2
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Essai: ≥80% (SDS-PAGE)
• Forme: frozen liquid
• Poids mol.: ~21 kDa
• Conditionnement: pkg of 10 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Concentration: 1250 μg/mL
• Couleur: clear colorless
• Numéro d'accès NCBI: NM_000594
• Numéro d'accès UniProt: P01375
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... TNF(7124)

Description

Description générale

Tumor necrosis factor α (TNFα or TNFSF2) is encoded by the gene mapped to human chromosome 6p21.33.

Actions biochimiques/physiologiques

Tumor necrosis factor α (TNFα or TNFSF2) is produced by many different cell types including activated monocytes, fibroblasts, endothelial cells, macrophages, T-cells, B-lymphocytes, granulocytes, smooth muscle cells, eosinophilis, chondrocytes and other cell types. It functions as a cytokine involved in cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. High level of TNFα leads to the development of inflammatory responses that are hallmarks of many diseases including autoimmune diseases, insulin resistance and cancer. The active form of TNFα (18 kDa) is generated by the cleavage of an Ala-Val bond between residues 76-77 of the precursor protein.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable