T104

Tropisetron

solid, ≥98% (HPLC)

• Synonyme(s) : ICS-205,930, Navoban, endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-ol Indol-3-yl-carboxylate hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₂₀N₂O₂ · HCl
• CAS Number: 105826-92-4
• Poids moléculaire : 320.81
• Numéro MDL: MFCD00210221
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278133
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: solid
• Solubilité: H₂O: >10 mg/mL
• Auteur: Novartis
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
• InChI: 1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H
• Clé InChI: XIEGSJAEZIGKSA-UHFFFAOYSA-N
• Informations sur le gène: human ... CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242) ; rat ... Chrna7(25302), Drd2(24318), Htr1a(24473), Htr3a(79246)

Description

Application

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

Actions biochimiques/physiologiques

3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT₃ serotonin receptor antagonist.

Selective 5-HT₃ serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

Caractéristiques et avantages

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)