T3202

Torsemide

≥98% (HPLC), solid

• Synonyme(s) : Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
• Formule empirique (notation de Hill) : C₁₆H₂₀N₄O₃S
• CAS Number: 56211-40-6
• Poids moléculaire : 348.42
• Numéro MDL: MFCD00866166
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826741
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Solubilité: DMSO: soluble 18 mg/mL; H₂O: insoluble
• Auteur: Roche
• Chaîne SMILES: CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2
• InChI: 1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
• Clé InChI: NGBFQHCMQULJNZ-UHFFFAOYSA-N
• Informations sur le gène: human ... SLC12A1(6557)

Description

Application

Torsemide has been used as an inhibitor of Na⁺ Cl^- co-transporter in transgenic Arabidopsis thaliana plants¹.

Actions biochimiques/physiologiques

Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure².

Torsemide is a loop diuretic and inhibitor of the Na⁺/K⁺/2Cl^- carrier system.

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na⁺/K⁺/2Cl^- carrier system.

Caractéristiques et avantages

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Notes préparatoires

Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319,H361fd
• Conseils de prudence: P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Eye Irrit. 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves