T4626

N_α-p-Tosyl-L-arginine methyl ester hydrochloride

≥98% (TLC), suitable for ligand binding assays

• Synonyme(s) : TAME hydrochloride
• Formule linéaire : H₂NC(=NH)NH(CH₂)₃CH(NHSO₂C₆H₄CH₃)CO₂CH₃ · HCl
• CAS Number: 1784-03-8
• Poids moléculaire : 378.87
• Beilstein: 3922357
• Numéro CE : 217-235-1
• Numéro MDL: MFCD00012578
• Code UNSPSC : 12352103
• eCl@ss : 32160406
• ID de substance PubChem : 24900058
• Nomenclature NACRES : NA.26

Propriétés

• Product Name: N_α-p-Tosyl-L-arginine methyl ester hydrochloride,
• Essai: ≥98% (TLC)
• Niveau de qualité: 200
• Forme: powder
• Technique(s): ligand binding assay: suitable
• Couleur: white
• Pf: 145-147 (lit.)
• Température de stockage: −20°C
• Chaîne SMILES: Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1
• InChI: 1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1
• Clé InChI: JIQFFACVQXXHMY-YDALLXLXSA-N

Description

Application

Nα-p-Tosyl-L-arginine methyl ester hydrochloride has been used as an esterolytic substrate to assess trypsin-like activity in midgut extracts. It has also been used as a substrate for measuring trypsin activity of pancreatin and human intestinal samples.

Actions biochimiques/physiologiques

N_α-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

Substrats

Substrate for trypsin, thrombin, plasmin, and other proteases.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)