T7947

(R)-Tomoxetine hydrochloride

solid

• Synonyme(s) : (R)-N-Methyl-γ-(2-methyl­phenoxy)benzenepropanamine hydrochloride, Atomoxetine hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₂₁NO · HCl
• CAS Number: 82248-59-7
• Poids moléculaire : 291.82
• Numéro MDL: MFCD06410992
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278760
• Nomenclature NACRES : NA.77

Propriétés

• Forme: solid
• Niveau de qualité: 100
• Auteur: Eli Lilly
• Température de stockage: 2-8°C
• Chaîne SMILES: CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
• InChI: 1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
• Clé InChI: LUCXVPAZUDVVBT-UNTBIKODSA-N
• Informations sur le gène: human ... SLC6A2(6530)

Description

Application

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:

• to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice
• to study its effects on set shifting in rats
• to study its effects on rat brain as a result of its long-term use

Actions biochimiques/physiologiques

(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters. It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC). (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter. It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).

Norepinephrine uptake blocker.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)