T8325

TDZD-8

≥98% (HPLC), needles

• Synonyme(s) : 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
• Formule empirique (notation de Hill) : C₁₀H₁₀N₂O₂S
• CAS Number: 327036-89-5
• Poids moléculaire : 222.26
• Numéro MDL: MFCD04973552
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826879
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: needles
• Conditions de stockage: protect from light
• Couleur: white
• Pf: 63-64.4 °C
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CN1SC(=O)N(Cc2ccccc2)C1=O
• InChI: 1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
• Clé InChI: JDSJDASOXWCHPN-UHFFFAOYSA-N

Description

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Actions biochimiques/physiologiques

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

TDZD-8 is a selective inhibitor of GSK-3.

Caractéristiques et avantages

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves