T9025

Thioridazine hydrochloride

≥99%

• Synonyme(s) : 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
• Formule empirique (notation de Hill) : C₂₁H₂₆N₂S₂ · HCl
• CAS Number: 130-61-0
• Poids moléculaire : 407.04
• Numéro CE : 204-992-8
• Numéro MDL: MFCD00012655
• Code UNSPSC : 12352200
• ID de substance PubChem : 57654711
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥99%
• Solubilité: H₂O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow; chloroform: soluble; diethyl ether: insoluble; ethanol: soluble; methanol: soluble
• Chaîne SMILES: Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1
• InChI: 1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
• Clé InChI: NZFNXWQNBYZDAQ-UHFFFAOYSA-N
• Informations sur le gène: human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)

Description

Application

Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.

Actions biochimiques/physiologiques

D₂ dopamine receptor antagonist; phenothazine antipsychotic with reduced extrapyramidal side effects; Ca²⁺ channel blocker.

Notes préparatoires

250 mg of thioridazine hydrochloride is soluble in 5 ml of water and yields a clear, colorless to faint yellow solution. Thioridazine hydrochloride is also soluble in methanol, ethanol, and chloroform, but it is insoluble in ether.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves