UC126

4-Hydroxymephenytoin

• Synonyme(s) : (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione
• Formule empirique (notation de Hill) : C₁₂H₁₄N₂O₃
• CAS Number: 61837-65-8
• Poids moléculaire : 234.25
• Numéro MDL: MFCD00142316
• Code UNSPSC : 12161501
• ID de substance PubChem : 24724640
• Nomenclature NACRES : NA.77

Propriétés

• Forme: solid
• Niveau de qualité: 200
• Couleur: white
• Pf: 153-154 °C
• Température de stockage: 2-8°C
• Chaîne SMILES: CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2
• InChI: 1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)
• Clé InChI: OQPLORUDZLXXPD-UHFFFAOYSA-N

Description

Description générale

CYP2C19 metabolite of mephenytoin.

Application

4-Hydroxymephenytoin has been used for developing ultra performance LC (UPLC)- tandem mass spectrometry (MS/MS) assays for evaluating cytochrome P450 (CYP) probe drugs and their relevant metabolites in human urine or plasma samples. 4-hydroxymephenytoin has also been used for developing sub-2-micron particle LC/MS/MS-based methods for analyzing CYP450 probe substrate metabolites.

Actions biochimiques/physiologiques

4-Hydroxymephenytoin catabolism displays genetic polymorphism and is a direct indicator of Cytochrome P450 2C19 (CYP2C19) activity. Detection and quantification of 4-hydroxymephenytoin in biological samples by HPLC method is well optimized.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)