W1628

Wortmannin

from Penicillium funiculosum, ≥98% (HPLC and TLC)

• Synonyme(s) : KY 12420
• Formule empirique (notation de Hill) : C₂₃H₂₄O₈
• CAS Number: 19545-26-7
• Poids moléculaire : 428.43
• Beilstein: 67676
• Numéro MDL: MFCD00133927
• Code UNSPSC : 12352207
• ID de substance PubChem : 24278777
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Penicillium funiculosum
• Niveau de qualité: 300
• Essai: ≥98% (HPLC and TLC)
• Forme: powder
• Couleur: off-white
• Solubilité: DMSO: soluble; H₂O: unstable
• Température de stockage: 2-8°C
• Chaîne SMILES: [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C3=C2C(=O)c4occ5C(=O)O[C@H](COC)[C@@]3(C)c45
• InChI: 1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
• Clé InChI: QDLHCMPXEPAAMD-QAIWCSMKSA-N
• Informations sur le gène: human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)

Description

Actions biochimiques/physiologiques

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM.

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.

Caractéristiques et avantages

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This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H310 + H330
• Conseils de prudence: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classification des risques: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges