W2020

WR-1065

≥98% (HPLC)

• Synonyme(s) : 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride, WR-1065 dihydrochloride
• Formule empirique (notation de Hill) : C₅H₁₄N₂S · 2HCl
• CAS Number: 14653-77-1
• Poids moléculaire : 207.16
• Numéro MDL: MFCD00460339
• Code UNSPSC : 12352200
• ID de substance PubChem : 329830444
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: H₂O: ≥20 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: Cl.Cl.NCCCNCCS
• InChI: 1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H
• Clé InChI: XDRLRDHLCIFZIW-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

WR-1065 is a cytoprotective cell-permeable ROS scavenge and an active metabolite of Amifostine.

WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.

WR-1065 is the active metabolite of the prodrug amifostine, generated by alkaline phosphatase. It is found to accumulate in many epithelial tissues. WR-1065 protects cellular membranes and DNA from free radical induced damage.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H318
• Conseils de prudence: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
• Classification des risques: Acute Tox. 4 Oral - Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable