Z2126

ZAP-70 Tyrosine Kinase human

≥90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ≥150 U/mg

• Numéro MDL: MFCD03459122
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Produit recombinant: expressed in baculovirus infected insect cells (Histidine tagged)
• Niveau de qualité: 200
• Essai: ≥90% (SDS-PAGE)
• Forme: buffered aqueous glycerol solution
• Activité spécifique: ≥150 U/mg
• Poids mol.: 70 kDa
• Numéro d'accès UniProt: P43403
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... ZAP70(7535)

Description

Application

Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.

Actions biochimiques/physiologiques

ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.

ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.

Définition de l'unité

One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 °C at pH 7.0.

Forme physique

Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1