SRP3066

IGF-Binding Protein 7 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 别名: PGI2-stimulating factor, PSF, Prostacyclin-stimulating factor, Tumor-derived adhesion factor (TAF), IBP-7, IGF binding protein related protein-1 (IGFBPrP1), Mac25
• UNSPSC代码: 51111800
• NACRES: NA.32

属性

• 生物来源: human
• 重组: expressed in E. coli
• 方案: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 表单: lyophilized
• 分子量: 26.4 kDa
• 包装: pkg of 25 μg
• 杂质: <0.1 EU/μg endotoxin, tested
• 颜色: white to off-white
• UniProt登记号: Q16270
• 运输: wet ice
• 储存温度: −20°C
• 基因信息: human ... IGFBP7(3490)

说明

一般描述

IGFBP7 (insulin-like growth factor-binding protein 7) is from the IGFBP superfamily and is widely expressed in tissues. It contains 11 cysteines, a heparin-binding site, a Kazal-type trypsin inhibitor domain and a carboxyl-terminal immunoglobulin-like type C repeat. The IGFBP7 gene is mapped to human chromosome 4q12.

生化/生理作用

IGFBP7 (insulin-like growth factor-binding protein 7) works as a tumor suppressor as well as an oncogene by controlling cell proliferation, cell attachment, apoptosis and angiogenesis. It is also involved in TGFβ (transforming growth factor β) signal pathway. IGFBP7 also interferes with the insulin pathway and is associated with the development of diabetes as well as cardiovascular diseases.IGFBP7 binds weakly to IGFs (insulin like growth factors) and strongly to insulin. It mainly participates in IGF-independent pathways.

序列

MSSSDTCGPC EPASCPPLPP LGCLLGETRD ACGCCPMCAR GEGEPCGGGG AGRGYCAPGM ECVKSRKRRK GKAGAAAGGP GVSGVCVCKS RYPVCGSDGT TYPSGCQLRA ASQRAESRGE KAITQVSKGT CEQGPSIVTP PKDIWNVTGA QVYLSCEVIG IPTPVLIWNK VKRGHYGVQR TELLPGDRDN LAIQTRGGPE KHEVTGWVLV SPLSKEDAGE YECHASNSQG QASASAKITV VDALHEIPVK KGEGAEL

外形

Lyophilized from 10 mM Sodium Phosphate, pH 6.8.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable