SML1083

Ethacrynsäure

≥97% (HPLC)

• Synonym(e): [2,3-Dichlor-4-(2-methylenbutyryl)-phenoxy]-essigsäure
• Empirische Formel (Hill-System): C₁₃H₁₂Cl₂O₄
• CAS Number: 58-54-8
• Molekulargewicht: 303.14
• EG-Nummer: 200-384-1
• MDL-Nummer: MFCD00056693
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 329825461
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
• InChI: 1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
• InChIKey: AVOLMBLBETYQHX-UHFFFAOYSA-N
• Angaben zum Gen: human ... SLC12A1(6557)

Beschreibung

Biochem./physiol. Wirkung

Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable