T6397

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

• Sinónimos: Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Fórmula empírica (notación de Hill): C₁₅H₁₁I₃NNaO₄
• CAS Number: 55-06-1
• Peso molecular: 672.96
• Beilstein: 8179867
• Número CE: 200-223-5
• Número MDL: MFCD00002594
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24900372
• NACRES: NA.77

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 200
• Línea del producto: BioReagent
• Ensayo: ≥95%
• Formulario: powder
• potencia: 0.02-50 ng/mL (lit.)
• técnicas: cell culture | mammalian: suitable
• solubilidad: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• Clave InChI: SBXXSUDPJJJJLC-YDALLXLXSA-M
• Información sobre el gen: human ... THRA(7067), THRB(7068) ; rat ... Thra(81812), Thrb(24831)

Descripción

Descripción general

3,3′,5′-Triiodo-L-thyronine (T₃) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T₄) serves as a precursor for T₃ and is generated in extrathyroidal tissues.

Aplicación

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Acciones bioquímicas o fisiológicas

3,3′,5′-Triiodo-L-thyronine (T₃) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T₃ regulates cell differentiation and protein expression. The interaction of T₃ with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T₃ hormone is reduced in hypothyroidism.

Forma física

powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstitución

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)