SAB4503051

Anti-Tyrosinase antibody produced in rabbit

affinity isolated antibody

• Synonym(s): LB24-AB, Monophenol monooxygenase, SK29-AB, TYR, Tumor rejection antigen AB
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 60 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; western blot: 1:500-1:1000
• NCBI accession no.: P14679
• UniProt accession no.: P14679
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TYR(7299)

Description

General description

Anti-Tyrosinase Antibody detects endogenous levels of total Tyrosinase protein.

The TYR (tyrosinase) gene is mapped to human chromosome 11q14.3 and codes for a membrane glycoprotein, tyrosinase. It is ubiquitously expressed in plant and animal tissue.

Immunogen

The antiserum was produced against synthesized peptide derived from human Tyrosinase.

Immunogen Range: 471-520

Biochem/physiol Actions

The encoded protein, tyrosinase, is involved in melanin production by catalyzing the oxidation of L-tyrosine and L- 3, 4-dihydroxyphenylalanine to form dopaquinone. TYR (tyrosinase) is associated with the development of neural crest cell into melanocytes. Biallelic mutations in the TYR gene results in an autosomal recessive disorder, oculocutaneous albinism type 1. Loss of tyrosinase activity contributes to the severity of this disorder, in which melanin is undetectable. Abnormal expression of the gene has been observed in atypical fibroxanthoma.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable