M8816
Microsomes from Liver, Pooled
from Monkey(Cynomolgus spp.), male
Synonym(s):
lab equipment accessory
biological source
Monkey (Cynomolgus spp.)
form
liquid
specific activity
≥5000 units/mg protein
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
Application
Microsomes from Liver, Pooled has been used to measure the in vitro stabilities of the prodrugs. It has also been used in microsomal incubation to generate BTX-3 metabolites to serve as references for liquid chromatography with tandem mass spectrometry (LC-MS/MS) analyses of urine.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomal cytochrome P450 proteins can catalyze the transfer of a single oxygen atom to endogenous and exogenous compounds, like steroids and phenobarbital, meant for excretion and detoxification.
Source of drug metabolizing enzymes, including cytochrome P-450.
Unit Definition
One unit will produce 1.0 picomole of 6 beta-hydroxytestosterone per minute at pH 7.4 at 37 deg C.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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