123129

2-Aminothiazole

97%

• Synonym(s): 2-Thiazolamine
• Empirical Formula (Hill Notation): C₃H₄N₂S
• CAS Number: 96-50-4
• Molecular Weight: 100.14
• Beilstein: 105738
• EC Number: 202-511-6
• MDL number: MFCD00005325
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847523
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• mp: 91-93 °C (lit.)
• solubility: 1 M HCl: soluble 50 mg/mL, clear (dark yellow-brown)
• SMILES string: Nc1nccs1
• InChI: 1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
• InChI key: RAIPHJJURHTUIC-UHFFFAOYSA-N

Description

Application

2-Aminothiazole was used in the synthesis of 2-aminothiazole-modified silica gel. It was used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.

Biochem/physiol Actions

2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves