125180

1-(3-Chlorophenyl)piperazine hydrochloride

99%

• Synonym(s): m-CPP
• Empirical Formula (Hill Notation): C₁₀H₁₃ClN₂ · xHCl
• CAS Number: 65369-76-8
• Molecular Weight: 196.68 (free base basis)
• EC Number: 265-718-0
• MDL number: MFCD00039032
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847652
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 99%
• form: powder
• mp: 210-214 °C (dec.) (lit.)
• solubility: methanol: soluble
• functional group: chloro
• SMILES string: Cl.Clc1cccc(c1)N2CCNCC2
• InChI: 1S/C10H13ClN2.ClH/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13;/h1-3,8,12H,4-7H2;1H
• InChI key: MHXPYWFZULXYHT-UHFFFAOYSA-N
• Gene Information: rat ... Htr1a(24473)

Description

General description

1-(3-Chlorophenyl)piperazine hydrochloride is sold as Ecstasy mimic tablets and is the major metabolite of the antidepressant medications trazodone and nefazodone.

Application

1-(3-Chlorophenyl)piperazine hydrochloride (CPP) has been used in determination of designer piperazines in urine specimens using GC-MS and LC-ESI-MS. CPP has been used to investigate the in vitro efficacy of newly synthesized compounds such as fluoroquinolones (norfloxacine and lomefloxacine) against Philasterides dicentrarchi .

Biochem/physiol Actions

1-(3-Chlorophenyl)piperazine induces hypophagia in food-deprived and freely feeding rats. CPP has affinity for 11 neurotransmitter receptor binding sites in human brain membranes.

5-HT_2c serotonin receptor agonist; metabolite of trazodone.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves