192333

Ethyl nitroacetate

97%

• Synonym(s): 2-Nitroacetic acid ethyl ester, Ethyl 2-nitroacetate, Nitroacetic acid ethyl ester
• Linear Formula: NO₂CH₂CO₂C₂H₅
• CAS Number: 626-35-7
• Molecular Weight: 133.10
• Beilstein: 1210027
• EC Number: 210-944-7
• MDL number: MFCD00007403
• UNSPSC Code: 12352100
• PubChem Substance ID: 24851540
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 97%
• refractive index: n20/D 1.424 (lit.)
• bp: 105-107 °C/25 mmHg (lit.)
• density: 1.199 g/mL at 25 °C (lit.)
• functional group: amine; ester; nitro
• SMILES string: CCOC(=O)C[N+]([O-])=O
• InChI: 1S/C4H7NO4/c1-2-9-4(6)3-5(7)8/h2-3H2,1H3
• InChI key: FTKASJMIPSSXBP-UHFFFAOYSA-N

Description

Application

Ethyl nitroacetate has been used in:

• synthesis of γ-oxoacids via Michael addition reaction with α,β-unsaturated ketones
• fuctionalization of C4-position on pyrimidine and C6-position on 2′-deoxyguanosine to produce novel nucleosides
• facile synthesis of α,α-diisobutylglycine
• synthesis of DL-4,4-difluoroglutamic acid

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): 197.6 °F - closed cup
• Flash Point(C): 92 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves