193984

1-Methylindole

≥97%

• Synonym(s): NSC 212534
• Empirical Formula (Hill Notation): C₉H₉N
• CAS Number: 603-76-9
• Molecular Weight: 131.17
• Beilstein: 111026
• EC Number: 210-057-5
• MDL number: MFCD00005800
• UNSPSC Code: 12352100
• PubChem Substance ID: 24851625
• NACRES: NA.22

Properties

• Assay: ≥97%
• form: liquid
• refractive index: n20/D 1.606 (lit.)
• bp: 133 °C/26 mmHg (lit.)
• density: 1.051 g/mL at 20 °C (lit.)
• SMILES string: Cn1ccc2ccccc12
• InChI: 1S/C9H9N/c1-10-7-6-8-4-2-3-5-9(8)10/h2-7H,1H3
• InChI key: BLRHMMGNCXNXJL-UHFFFAOYSA-N

Description

General description

1-Methylindole undergoes Au(III)/TPPMS-catalyzed benzylation reaction with benzhydryl and benzylic alcohols.

Application

1-Methylindole was used in the determination of association constant for the electron-donor-acceptor complexes of 1-methylindole with 1-(2,4,6-trinitrophenyl) propan-2-one.

Reactant for preparation of:

• Pharmaceutically active 2-oxo-1-pyrrolidine analogues
• Non-receptor tyrosine kinase (Src kinase) inhibitors
• PET agents for imaging of protein kinase C (PKC)
• Ynediones as highly reactive Michael systems
• Anticancer agents
• Polycyclic derivatives of indoles
• PET agents for imaging of glycogen synthase kinase-3 (GSK-3)
• Anti-prion disease agents
• Bisindole derivatives with antihyperlipidemic activity
• PET cancer imaging agents

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves