232904

Methyl 3-amino-2-thiophenecarboxylate

99%

• Empirical Formula (Hill Notation): C₆H₇NO₂S
• CAS Number: 22288-78-4
• Molecular Weight: 157.19
• EC Number: 244-895-8
• MDL number: MFCD00009765
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853938
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 99%
• form: solid
• bp: 100-102 °C/0.1 mmHg (lit.)
• mp: 62-64 °C (lit.)
• functional group: ester
• SMILES string: COC(=O)c1sccc1N
• InChI: 1S/C6H7NO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,7H2,1H3
• InChI key: TWEQNZZOOFKOER-UHFFFAOYSA-N

Description

General description

Methyl 3-amino-2-thiophenecarboxylate reacts with hydrazonoyl chlorides in the presence of triethylamine to yield corresponding N-arylamidrazones.

Application

Methyl 3-amino-2-thiophenecarboxylate was used in:

• the synthesis of 4-nitro and 4-aminothienyl ureas
• total synthesis of quinazolinocarboline alkaloids
• preparation of thienopyrimidinone analogs

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves