383449

3-Formylchromone

97%

• Synonym(s): 4-Oxo-4H-1-benzopyran-3-carboxaldehyde
• Empirical Formula (Hill Notation): C₁₀H₆O₃
• CAS Number: 17422-74-1
• Molecular Weight: 174.15
• EC Number: 241-451-5
• MDL number: MFCD00014667
• UNSPSC Code: 12352100
• PubChem Substance ID: 24863967
• NACRES: NA.22

Properties

• Assay: 97%
• form: solid
• mp: 151-153 °C (lit.)
• functional group: aldehyde; ketone
• SMILES string: O=CC1=COc2ccccc2C1=O
• InChI: 1S/C10H6O3/c11-5-7-6-13-9-4-2-1-3-8(9)10(7)12/h1-6H
• InChI key: FSMYWBQIMDSGQP-UHFFFAOYSA-N
• Gene Information: human ... PTPN1(5770)

Description

General description

Electrospray ionization mass spectrometry (ESI-MS) of protonated 3-formylchromone (3-FC) shows loss of H₂ as a major fragmentation route to yield a ketene cation, which on reaction with water forms a protonated carboxylic acid. The invivo salubrious effects of 3-FC against nitrosodiethylamine (NDEA) mediated early hepatocellular carcinogenesis has been investigated. Synthesis and characterization of 3-FC and its derivatives has been reported.

Application

3-Formylchromone may be used in the following studies:

• Preparation of library of novel (E)-3-(2-arylcarbonyl-3-(arylamino)allyl)-4H-chromen-4-ones, by three-component domino reactions with (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones and anilines under catalyst-free conditions.
• Facile and ecofriendly synthesis of new chromonyl chalcones.
• Synthesis of 3-(2-hydroxybenzoyl)quinolines and 7H-chromeno[3,2-c]quinolin-7-ones.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves