437786

Diethyl chloromalonate

95%

• Linear Formula: ClCH(CO₂C₂H₅)₂
• CAS Number: 14064-10-9
• Molecular Weight: 194.61
• EC Number: 237-913-0
• MDL number: MFCD00009140
• UNSPSC Code: 12352100
• PubChem Substance ID: 24867397
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 95%
• form: liquid
• refractive index: n20/D 1.432 (lit.)
• density: 1.204 g/mL at 25 °C (lit.)
• functional group: chloro; ester
• SMILES string: CCOC(=O)C(Cl)C(=O)OCC
• InChI: 1S/C7H11ClO4/c1-3-11-6(9)5(8)7(10)12-4-2/h5H,3-4H2,1-2H3
• InChI key: WLWCQKMQYZFTDR-UHFFFAOYSA-N

Description

General description

Diethyl chloromalonate (Diethyl α-chloromalonate) is a 2-halo-1,3-dicarbonyl compound. It participates in K₂CO₃-catalyzed domino reactions (Michael alkylation, Mannich alkylation, and aldol alkylation) of salicylic aldehyde derivatives to afford functionalized 2,3-dihydrobenzofurans. It reacts with Cs₂CO₃ in the presence of elemental S₈ or Se_n to afford the corresponding diethyl thioxo- or selenoxomalonates, which can be trapped in situ with various 1,3-dienes.

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H314,H335,H400
• Precautionary Statements: P261 - P271 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves