459135

Tetramethylammonium fluoride

97%

• Synonym(s): TMAF
• Linear Formula: (CH₃)₄NF
• CAS Number: 373-68-2
• Molecular Weight: 93.14
• EC Number: 206-769-0
• MDL number: MFCD00011627
• UNSPSC Code: 12352116
• PubChem Substance ID: 24869514
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• form: solid
• mp: 170 °C (dec.) (lit.)
• functional group: amine
• SMILES string: [F-].C[N+](C)(C)C
• InChI: 1S/C4H12N.FH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1
• InChI key: GTDKXDWWMOMSFL-UHFFFAOYSA-M

Description

Application

Reactant for:

• Halide-induced ring opening of 2-substituted aziridinium salts
• Synthesis of fluoro aromatics via fluorodenitration reactions
• Synthesis of sevoflurane in ionic liquids by halogen-exchange fluorination
• Synthesis of fluorinated Poly(oxomolybdates)

Tetramethylammonium fluoride may be used in combination with sulfuryl fluoride for the conversion of aryl phenols to aryl fluorides. It can react with aminosilanes to generate onium amide bases in situ, which can deprotonate heteroarenes.

Useful for halogen exchange.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332,H315,H319,H335
• Precautionary Statements: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves