544272

5-Chlorothiophene-2-sulfonyl chloride

96%

• Empirical Formula (Hill Notation): C₄H₂Cl₂O₂S₂
• CAS Number: 2766-74-7
• Molecular Weight: 217.09
• MDL number: MFCD00051667
• UNSPSC Code: 12352100
• PubChem Substance ID: 24878721
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 96%
• refractive index: n20/D 1.586 (lit.)
• bp: 112-117 °C (lit.)
• density: 1.623 g/mL at 25 °C (lit.)
• functional group: chloro
• storage temp.: 2-8°C
• SMILES string: Clc1ccc(s1)S(Cl)(=O)=O
• InChI: 1S/C4H2Cl2O2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H
• InChI key: SORSTNOXGOXWAO-UHFFFAOYSA-N

Description

General description

5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.

Application

5-Chlorothiophene-2-sulfonyl chloride may be used in the preparation of:

• (S)-N-(5-chlorothiophene-2-sulfonyl)-β,β-diethylalaninol
• N-(3-(1H-pyrazol-1-yl)pyridin-2-yl)-5-chlorothiophene-2-sulfonamide
• 5-chloro-4-nitrothiophene-2-sulfonyl chloride

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves