906107
(9-Aminononyl)triphenylphosphonium bromide
90%
Synonym(s):
Aminononane TPP mitochondrial tag, Mitochondria-targeting probe building block, Phosphonium lipocation tag
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About This Item
Empirical Formula (Hill Notation):
C27H35BrNP
Molecular Weight:
484.45
UNSPSC Code:
12352200
Assay
90%
form
powder
storage temp.
2-8°C
SMILES string
NCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]
Application
Mitochondria perform several functions in the cell, and dysfunction has been implicated in various organ systems and disease states, including neurodegenerative disorders, cardiovascular diseases, and cancers. The targeting of small molecules to the mitochondria can help to probe and better understand this relationship or to increase therapeutic efficacy by concentrating a drug at its site of action and reducing off-target effects. This bromohexane triphenylphosphine (TPP) tag is conjugated to small molecules to localize them to the mitochondria in cells where the TPP cations facilitate both cellular uptake and accumulation in the mitochondria.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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