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Key Documents

914231

Sigma-Aldrich

4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride

≥95%

Synonym(s):

DAS1, SFABP, Sulfonyl fluoride activity-based probe

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About This Item

Empirical Formula (Hill Notation):
C14H16FNO3S
CAS Number:
Molecular Weight:
297.35
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22

Quality Level

Assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

F[S](=O)(=O)c1ccc(cc1)CCNC(=O)CCCC#C

InChI

1S/C14H16FNO3S/c1-2-3-4-5-14(17)16-11-10-12-6-8-13(9-7-12)20(15,18)19/h1,6-9H,3-5,10-11H2,(H,16,17)

InChI key

HWSJGTCAHFQVSV-UHFFFAOYSA-N

Application

4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride is an alkyne-functionalized sulfonyl fluoride activity-based probe (SFABP). Sulfonyl fluorides covalently modify reactive serines in addition to threonine, lysine, tyrosine, cysteine, and histidine residues in a context-specific manner. Activity-based probes are useful for the targeting, isolation, and identification of proteins. Furtermore, the alkyne handle on SFABP enables click chemistry-based incorpoation of azide tags, such as fluorophores or biotins, for visualization or enrichment and detection, respectively.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids


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