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920444

Sigma-Aldrich

mPEG functionalized gelatin

50% PEGylation, PEG average Mn 1k, gel strength 300 g Bloom

Synonym(s):

PEGylated Gelatin

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About This Item

Linear Formula:
(C32H50N9O12-)m(CH2CH2O)n
UNSPSC Code:
12352201
NACRES:
NA.23
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Quality Level

form

(solid or chunk(s) or fiber)

mol wt

PEG average Mn 1k

color

white to off-white

storage temp.

2-8°C

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900628900629900622
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

(solid or chunk(s) or fiber)

form

solid

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

color

white to off-white

color

-

color

-

color

-

mol wt

PEG average Mn 1k

mol wt

-

mol wt

-

mol wt

-

Application

mPEG functionalized gelatin is Type A gelatin grafted with PEG that can be used in drug delivery research. Gelatin is a denatured protein that is obtained by hydrolysis of animal collagen. Its biodegradability, biocompatibility, chemical modification potential and cross-linking possibility make gelatin-based nanoparticles (GNPs) a promising carrier system for drug delivery applications. mPEG functionalization has several advantages − prolonged circulation in the body, decreased degradation by metabolic enzymes, and reduction or elimination of protein immunogencity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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S C Perricone et al.
Journal of medicinal chemistry, 37(22), 3693-3700 (1994-10-28)
Random screening identified N,N'-dicyclohexyl-4-morpholinecarboxamidine (U-18177, 1) as an orally effective nonkaliuretic diuretic in rats. The diuretic profile of 1 and its 1-adamantyl analog (U-37883A, 4) was confirmed orally in dogs, when they were less potent than standard diuretics but showed
Earl R Kern et al.
Antimicrobial agents and chemotherapy, 46(4), 991-995 (2002-03-19)
The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication in vitro and in animal models when
Yuji Kamata et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 32(3), 220-226 (2009-03-06)
It is suggested that an ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein. We reported that glibenclamide, an ATP-sensitive potassium channel blocker, accelerated dose-dependent secretion of renal kallikrein in sliced kidney cortex and in vivo

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