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Key Documents

925136

Sigma-Aldrich

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

Synonym(s):

2-Sulfonylpyridine, Cysteine-reactive electrophile, SNAr probe

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About This Item

Empirical Formula (Hill Notation):
C8H10N2O3S
CAS Number:
Molecular Weight:
214.24
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22

reaction suitability

reagent type: chemical modification reagent

Quality Level

storage temp.

2-8°C

Application

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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