934402

2-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-yl)isoindole-1,3-dione hydrochloride

≥95%

• Synonym(s): 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-piperidinyl)-, hydrochloride, 2-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-yl)isoindoline-1,3-dione
• Empirical Formula (Hill Notation): C₁₈H₁₉N₃O₄ · xHCl
• Molecular Weight: 341.36 (free base basis)
• MDL number: MFCD34571122
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder
• storage temp.: 2-8°C
• SMILES string: N1CCC(CC1)c2cc3c(cc2)C(=O)N(C3=O)C4CCC(=O)NC4=O
• InChI: 1S/C18H19N3O4/c22-15-4-3-14(16(23)20-15)21-17(24)12-2-1-11(9-13(12)18(21)25)10-5-7-19-8-6-10/h1-2,9-10,14,19H,3-8H2,(H,20,22,23)
• InChI key: KOGMQASWKIDFRN-UHFFFAOYSA-N

Description

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.


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Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable