QBD10247

Thiol-dPEG^®₄-acid

>95% (HPLC)

• Synonym(s): Carboxy-PEG₄-thiol, HS-PEG₄-COOH, Thiol-PEG-acid, Thiol-PEG₄-COOH, Thiol-PEG₄-acid
• Empirical Formula (Hill Notation): C₁₁H₂₂O₆S
• Molecular Weight: 282.35
• MDL number: MFCD11041132
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• Assay: >95% (HPLC)
• form: solid or viscous liquid
• reaction suitability: reaction type: Pegylations
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: SCCOCCOCCOCCOCCC(=O)O
• InChI: 1S/C11H22O6S/c12-11(13)1-2-14-3-4-15-5-6-16-7-8-17-9-10-18/h18H,1-10H2,(H,12,13)
• InChI key: ORLGUGSEJFKLED-UHFFFAOYSA-N

Description

Features and Benefits

Thiol-dPEG₄-acid is a sulfhydryl-containing, crosslinking PEGylation reagent that has a cross-bridge of monodisperse polyethylene glycol. The single molecular weight, discrete-length PEG (dPEG) chain is 16 atoms (18.3 Å) long. The sulfhydryl end of the crosslinker reacts with gold (forming dative bonds) and with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable