700055P

5α,6β-dihydroxycholestanol-d7

Avanti Research^™ - A Croda Brand

• Synonym(s): 3β,5α,6β-trihydroxycholestane (d7)
• Empirical Formula (Hill Notation): C₂₇H₄₁D₇O₃
• CAS Number: 127684-07-5
• Molecular Weight: 427.71
• MDL number: MFCD34568136
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• description: cholestane-3β,5α,6β-triol-d7
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (700055P-1mg); pkg of 1 × 5 mg (700055P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)[C@@]3(O)[C@H](O)C2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
• InChI key: YMMFNKXZULYSOQ-UCHKBJBUSA-N

Description

General description

5α,6β-dihydroxycholestanol is a structural derivative of cholesterol and is an abundant oxysterols. 5α,6β-dihydroxycholestanol-d7 is a deuterated form of 5α,6β-dihydroxycholestanol.

Application

5α,6β-dihydroxycholestanol-d7 has been used as an analyte in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis based multiple reaction monitoring (MRM) studies and as an internal standard in tandem mass spectrometry (MS/MS) for analysis of plasma samples.

Biochem/physiol Actions

5α,6β-dihydroxycholestanol (5α,6β-diOH-Chol) or cholestane-3β,5α,6β-triol (C-triol) levels are elevated along with 7-ketocholesterol in Niemann-Pick type C (NP-C) disease and is a key biomarkers for detection. It has ,neuroprotective functionality and may elicit protection against neuronal injury during ischemia.

Packaging

5 mL Amber Glass Screw Cap Vial (700055P-1mg)

5 mL Amber Glass Screw Cap Vial (700055P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): No data available
• Flash Point(C): No data available