860053P

Ganglioside-Total

Avanti Research^™ - A Croda Brand

• Synonym(s): Total Ganglioside Extract (Brain, Porcine-Ammonium Salt)
• CAS Number: 383907-71-9
• MDL number: MFCD02266307
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 10 mg (860053P-10mg); pkg of 1 × 25 mg (860053P-25mg); pkg of 1 × 50 mg (860053P-50mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O[C@@H]4O[C@H](CO)[C@@H]([C@H](O[C@@H]5O[C@H

Description

General description

Gangliosides are glycosphingolipids, that contain sialic acid residues in the glycan chain. They are mainly present on the surface of neuronal cells. Gangliosides are also present in serum. Four complex ganglioside structures, such as GM1, GD1a, GD1b and GT1b are the most abundantly found ganglioside in mammalian brains. Gangliosides comprise a ceramide tail attached to a polar carbohydrate head.

Application

Ganglioside-Total may be used:

• as a standard to investigate the efficiency of ganglioside extraction in brain using electrospray ionization-mass spectrometry (ESI MS) analysis
• as a hemagglutinin (HA) binding receptor to assemble nanodisc with affinity to influenza virus (NDTG) and also to determine the effect of total ganglioside extract (TG) amount on total ganglioside
• in liposomes to measure ostreolysin A (OlyA) binding in order to deduce the effects of phosphatidylcholines (PCs) on sphingomyelin

Biochem/physiol Actions

Gangliosides regulate various biological activities in cell plasma membranes (PMs). It provides structural rigidity to the cell. Ganglioside clusters form membrane microdomains, which facilitates cell adhesion. It also functions as differentiating markers during oncogenesis, embryogenesis, lymphoid differentiation and neoplastic transformation. Gangliosides have the ability to repress cell-mediated immune functions. It is also associated with cancer and Alzheimer′s disease.

Packaging

5 mL Amber Glass Screw Cap Vial (860053P-10mg)

5 mL Amber Glass Screw Cap Vial (860053P-25mg)

5 mL Amber Glass Screw Cap Vial (860053P-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): No data available
• Flash Point(C): No data available