860477P

1-desoxymethylsphingosine

1-desoxymethylsphingosine (m17:1), powder

• Synonym(s): 1-Deoxymethylsphingosine
• Empirical Formula (Hill Notation): C₁₇H₃₅NO
• CAS Number: 1246303-16-1
• Molecular Weight: 269.47
• MDL number: MFCD22416651
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 1 mg (860477P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 860477P
• lipid type: sphingolipids; bioactive lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCC/C=C/[C@](O)([H])CN
• InChI: 1S/C17H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(19)16-18/h14-15,17,19H,2-13,16,18H2,1H3/b15-14+/t17-/m1/s1
• InChI key: NTZGVZKEAIALQE-IAOULYHDSA-N

Description

General description

1-desoxymethylsphingosine is synthesized from glycine in the presence of the enzyme serine palmitoyltransferase (SPT).

Application

1-desoxymethylsphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line.

Biochem/physiol Actions

1-desoxymethylsphingosine is less neurotoxic compared to 1-desoxysphingosine in dorsal root ganglion neuronscultures Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1), due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine which are further converted to -deoxy(methyl)-ceramide and 1-deoxy(methyl)-sphingosine (1-deoxy(methyl)-SO). However, they lack the hydroxyl group essential for glycosphingolipid generation, resulting in accumulation of intermediate products.

Packaging

5 mL Amber Glass Screw Cap Vial (860477P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3